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mirevtuximab or silent LALA mutant version of mirvetuximab Desired functional properties of the anti-FRa antibodies includes without limitation: an ADC with such variant anti-FRa antibody provides similar or lower in vitro efficacy in FRa negative cell line (such as BT-474 breast cancer cell lines) as the corresponding control ADC with mAb1 as the anti-FRa antibody, for example using an in vitro efficacy assay in FRa negative cell line as used in the Examples

4B) of N-CDs remained nearly unchanged by DOXY, suggesting the absence of fluorescence resonance energy transfer (FRET) or dynamic quenching effect (DQE) between N-CDs and DOXY

Beutler, 1975

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