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looked at some clinical trial studies (Phases II and III)

We will not only listen to your complaints, we understand them

PMC Journal

For example, the widely used chemotherapeutic drugs doxorubicin (DOX), cisplatin (CIS), Fluorouracil (5-FU), methotrexate (MTX) and tamoxifen (TAM) have high antitumor efficacy, meanwhile with serious damage to multiple organs (e.g., cardiomyopathy, acute renal failure, acute toxic leukoencephalopathy, hepatic steatosis and testicular toxicity) (154158)