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30 ChenS.GlawischnigE.JrgensenK.NaurP.JrgensenB.OlsenC

highlighted the neuroprotective efficacy of Wu-tou Decoction, which reduced levels of IL-1, CCL2, and CXCL1, while mitigating glial cell activation and neuroinflammation

2 Pathological mutations in any of these genes can lead to BH4 deficiency, it is not yet clear if there are polymorphisms that result in milder reductions in function