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A handful of peptides have been used in medicine for decades: First and most famously, insulin was made available in the 1920s

16 The expression levels of TGF- are elevated in the oral epithelium, up to the stratum spinosum from OSF patient tissue

These diseases not only impose a heavy burden on global public health systems but also constitute major clinical challenges due to their high incidence, complex pathogenesis, and limited treatment options