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2.2.3 Cancer stem cells One particular aspect of the TME worthy of note is the presence of cancer stem cells (CSCs) and their plasticitya property that enables cells to change their phenotypic expression as a result of environmental cues, without causing any genetic mutation

That means thats not natural

Science 250, 10021004

Dysfunction of this barrier and alterations in intestinal permeability, also known as leaky gut is an important topic for clinicians and researchers in all species including horses and humans