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Additionally, these mice exhibited reduced MMP and increased ROS levels in their oocytes, indicating mitochondrial dysfunction and oxidative stress imbalance

The NP is tightly enclosed by the circular AF that consists of water, NP cells, notochord cells (NCs), and extracellular matrix (ECM)

Based on these premises, antioxidant treatments have been extensively used to potentially improve sperm parameters and increase the likelihood of conception

An Nrf2 activator (hydralazine), which reduces ROS production in LECs in mice and humans, provides cytoprotection and delays lens opacification caused by aging and oxidative stress (410)