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12 Rats can metabolize APAP to form a reactive metabolite and cause GSH depletion and protein adducts formation, even in mitochondria

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Transplantation of senescent cells into young mice has been shown to reduce lifespan and increase frailty, with more severe effects observed in obese models compared to normal mice

Cancer prevention Studies are mixed on whether vitamin B12 in combination with folate and B6 can reduce cancer risk, and it may increase risk of lung or colorectal cancers