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These bioactive compounds play crucial roles in maintaining metabolic homeostasis, immune regulation, and endocrine function through multiple interconnected mechanisms ( At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics