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Foundational Research in Diet-Induced Obese Mice The frequently repeated weight and fat findings originate from a short mouse proof-of-concept study

Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13