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Along with histone H4 acetylation at multiple sites, other PTMs occur on histones prior to their turn-over, such as methylation, phosphorylation, crotonylation and ubiquitinylation of histone H3 and H2B residues (Wendt and Shilatifard, 2006

Furthermore, the cuprizone model allows to dissect the molecular mechanisms without the interference with the peripheral immune system, which is rather difficult in EAE

Fcy::Fur fusion catalyzes transformation processes wherein five-fluorocytosine (5-FC) is converted selectively, yielding toxic derivatives known as five-fluorouracil (5-FU), effectively targeting only malignant cellular populations without adversely affecting surrounding healthy tissue structures (85)

Please remember to prime your pen, says Richard Wood, a pharmacist at Simple Online Pharmacy