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In conclusion, natural remedies provide a multi-target strategy for chronic, symptomatic illnesses including dry eye disease (DED), while current medications are frequently curative

Regulating copper ion levels by modulating the copper efflux pathway ATP7A/B ATP7A/B is a Cu + transporter ATPase, which maintains copper homeostasis within cells and involves the transmembrane transfer of Cu + ions from the cytoplasm to receptor proteins, and requires ATP hydrolysis (Tury et al., 2023)