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That is, xCT inhibitors may exhibit anticancer properties against cancer cells with elevated GLUT1 expression in a high-glucose tumor environment, whereas glucose deprivation blocks ferroptosis-induced cell death [18,19] [Figure 2B]

Using them together means you're not relying on one pathway when you could be addressing two simultaneously

Another cause of deficiency may be due to medications such as proton pump inhibitors or metformin reducing B12 levels over time

Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome