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While many people associate metabolism simply with burning calories, the reality at the molecular level is a highly orchestrated process of converting molecular bonds into adenosine triphosphate (ATP), the universal energy currency of the cell

The partner protein Cockayne syndrome A (CSA, also known as ERCC8) and CSB (also known as ERCC6) ubiquitylation the Cterminal domain of RNA polymerase II, which arrested in the damaged coding region and initiated the normal NER through GGR signaling [36, 37]

In addition to cofactor requirements, some HDACs need to be in multi-protein corepressor complexes to achieve their full catalytic function

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