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These models, which integrate transcriptomics and consumption-release metabolomics data to predict metabolic fluxes, revealed unexpected metabolic features of FH-deficient cells

(2016) 6:e008680

Rapamycin, which induces autophagy through the inhibition of mTORC1, and wortmannin, which inhibits autophagy through inhibition of phosphatidylinositol-3-kinase (PI3K), were used as controls (Powis et al., 1994

The pharmacokinetic advantage is significant: systemic bioavailability of intranasal peptides is typically 1020%, but CNS bioavailability can reach 3060% because the compound travels directly along nerve sheaths into cerebrospinal fluid