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Arch Med Sci 3:112116 Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L (2016) Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle

It helps maintain cellular homeostasis by modulating oxidative stress, assisting in protein repair, supporting mitochondrial function, sustaining DNA integrity, and influencing inflammatory pathways

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MnO 2 NPs can also be used as a unique nutrition-responsive ICD inducer, selectively inducing ICD in nutrition-deficient tumor cells to regulate adaptive immunity (110)