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The OCR was measured in real-time, quantifying the picomoles of oxygen consumed per minute (pmol/min), and graphed over time, before and after the addition of Rotenone to the culture medium (baseline OCR and specifically used for measuring mitochondrial respiration)

Pharmacotherapy [12, 13] consists of four categories of drugs: (1) First-line drugs like anticonvulsants (gabapentin, pregabalin, and carbamazepine) and antidepressants (amitriptyline, duloxetine, and venlafaxine)

In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells