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VIC leads to the inhibition of cell proliferation and growth by generating ROS and altering the expression of genes involved in angiogenesis, glycolysis, and metastasis by regulating the transcriptional activity of hypoxia

Animal Model:0.5 million EGFR Del19/T790M/C797S Ba/F3 cells and 50% Matrigel gel were subcutaneously inoculated in Balb/c nude mice (female aged 6-8 weeks) [1] Dosage:20, 40 mg/kg Administration:p.o., once a day for 18 consecutive days Result:Significantly reduced tumor volume by 58% and 84% at doses of 20 mg/kg and 40 mg/kg

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Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles