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In addition, SLC7A11, the antiporter providing intracellular cystine (necessary to maintain intracellular GSH levels) also increased (Figure 2C and Supplemental Figure 2A)

JS-K, a glutathione/glutathione S -transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity

As a result, this process leads to tissue edema and fluid accumulation

Summary Keywords Pycnogenol , procyanidins, bioavailability, distribution, metabolism, elimination, pharmacokinetics Citation Bayer J and Hgger P (2024) Review of the pharmacokinetics of French maritime pine bark extract (Pycnogenol ) in humans