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The in vivo role of Set7/9 in ROS-associated pathological processes Considering the number of connections between Set7/9 and ROS regulatory proteins, it is not surprising that this methyltransferase was found to be an important contributor to ROS-associated pathological processes also at the organismal level

The magnitude and quality of the CD8 + T cell response dictate the formation of a competent pool of effector T cells, capable of trafficking into peripheral tissues and infiltrating the tumor microenvironment (TME), where they must overcome antigenic persistence, metabolic constrains and suppressive signals 6,7

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