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Shorter, thinner and stronger tibia bone in JA757 and thinner tibia bone in dual-purpose crossbreed in HR compared to the LR may be due to their higher locomotor activity on the range

However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications

Genome-wide activation screening identified that GCH1 and its metabolites BH 4 /BH 2 (dihydrobiopterin) inhibit ferroptosis via lipid remodeling, specifically by selectively protecting phospholipids containing two polyunsaturated fatty acyl chains and enhancing the reduced state of CoQ 10 (28)