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The observed reduction in postpartum estrus intervals and services per conception is consistent with findings in cattle, where Se supplementation, often in combination with vitamin E, has been shown to improve ovarian cyclicity, enhance progesterone production, and accelerate the resumption of estrous cycles after parturition [49, 50]

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Disclosures: Arunkumar Krishnan: Nothing to Disclose, Diptasree Mukherjee: Nothing to Disclose, Carolin Schneider: Nothing to Disclose, Tinsay Woreta: Nothing to Disclose, Saleh Alqahtani: Nothing to Disclose 1161 NOTCH SIGNALING DISRUPTION AND CELLULAR CROSSTALK: DISSECTING THE PATHOPHYSIOLOGY OF BILE DUCT PAUCITY IN ALAGILLE SYNDROME USING HUMAN LIVER ORGANOIDS Marie-Agns M'CALLUM 1 Quang Toan PHAM 1 Kristen Vieira-Lomasney 1 Eytan Haddad 1 Silvia Selleri 1 Massimiliano Paganelli 1 , 1 Liver Tissue Engineering and Cell Therapy Laboratory, CHU Sainte-Justine, Universit de Montral Background: Alagille syndrome (ALGS) is a multisystemic genetic disorder resulting in severe liver disease characterized by intrahepatic bile duct paucity