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17 : 132136 Krsmanovic LZ, Virmani MA, Stojilkovic SS, Catt KJ

In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients