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For patients with PD-L1- a/m TNBC disease, upcoming phase III trials to determine the optimal first-line therapy include the ASCENT-03 (NCT05382299) trial, which is investigating SG compared to treatment of physicians choice and TROPION-Breast 02 (NCT05374512), which investigates Dato-DXd against treatment of physicians choice

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Additionally, both AMPK and ULK1 can phosphorylate Atg9, a transmembrane protein involved in the early formation of autophagosomes, thereby exerting control over its localization