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Heterogeneity within GBM (regional genetic variance and cellular hierarchies often regulated by different CSC niches) is accepted as the basis for resistance to multiple treatments (155, 156)

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Diclofenac has known human metabolites that include (2S,3S,4S,5R)-6-[2-[2-(2,6-Dichloroanilino)phenyl]acetyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid, 4'-hydroxydiclofenac, and 5-hydroxydiclofenac