Aflatoxin B1 and M1: biological properties and their involvement in cancer development
The SURPASS trials in patients with type 2 diabetes showed significant improvements in insulin sensitivity, HbA1c, and metabolic parameters all factors that indirectly support testosterone production (Frias et al., 2021, NEJM )
[20,21] Overview of Cancer Therapeutic Agents Chemotherapy agents can be divided into several categories: alkylating agents (e.g., cyclophosphamide, ifosfamide), antibiotics which affect nucleic acids (e.g., doxorubicin, bleomycin), platinum compounds (e.g., cisplatin), mitotic inhibitors (e.g., vincristine), antimetabolites (e.g., 5-fluorouracil), camptothecin derivatives (e.g., topotecan), biological response modifiers (e.g., interferon), and hormone therapies (e.g., tamoxifen).The agents most noted for creating cellular damage by initiating free radical oxidants are the alkylating agents, the tumor antibiotics, and the platinum compounds
As our understanding of NAD+ biology continues to evolve, this fundamental coenzyme will likely remain at the forefront of research into aging, metabolism, and research interventions for age-related diseases