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In particular, proteasome inhibitors bortezomib, carfilzomib, and ixazomib were approved by the US Food and Drug Administration (FDA) for treatment of multiple myeloma in 2003, 2012, and 2015, respectively (Manasanch and Orlowski, 2017)

Therefore, we conclude that the combination of PTX and RSL3 can induce ferroptosis in TNBC cells by activating the NF-B signalling pathway, thereby increasing the chemosensitivity of TNBC to PTX