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In the presence of free iron ions, hydrogen peroxide (H 2 O 2 ) and superoxide (O 2 ) produce OH (hydroxyl radicals) via the Fenton and Haber-Weiss reactions ( in vivo is the most important chemical substance that initiates lipid peroxidation and causes DNA damage ( 2+ /Fe 3+ , iron ions near membrane lipids react with lipid peroxides to form new lipid peroxides and lipid oxygen free radicals, which further accelerate the chain reaction and eventually lead to cross-linking, polymerization, and inactivation of some lipids and functional macromolecular compounds ( Treatment of Iron Overload Iron chelating agents are the main treatment options for iron overload diseases

10.1016/j.tifs.2016.03.001 [DOI] [Google Scholar] Gonzales G

About 70 young canaries were raised by their parents to independence (40 days) under these sound conditions

These findings establish ABCC4 as a promising therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular diseases