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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

doi:10.3390/ijns5030029

However, in a world of plenty, this advantage would turn into a disadvantage and give fast increases in body weight, hyperinsulinemia, and the development of metabolic syndrome problems early on (reviewed by Dunger et al (48)

Carpal tunnel syndrome is caused by compression of the median nerve at the wrist it produces numbness, tingling, and weakness, especially at night, in the thumb-side fingers