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Further studies are required to elucidate in more detail the regulation of CrK in astrocytes, the intracellular distribution of CrK, the function of CrP as energy buffer for astrocytic ATP-consuming reactions and potential consequences of an altered astrocytic CrP metabolism in pathological conditions

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Genotype-specific responses, including polymorphisms in one-carbon metabolism and metabolic pathways, are discussed as key determinants of interindividual variation in methylation outcomes

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