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Apo B-48 permits lipid binding to the chylomicron but not does not bind to the low density lipoprotein receptor, thereby preventing premature clearance of chylomicrons from the circulation before they are acted upon by lipoprotein lipase (LPL)

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Furthermore, following distribution, EXOs experience physiological alterations that are still unclear and pose serious translational hazards, including morphological reconstruction, cargo disintegration, or fusion with undesired cells (Nakase, 2021)