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To recapitulate this model ex vivo, we treated slices with 1 mM CPZ and 15 ng/mL rapamycin continuously for 1 week, in an attempt to sustain CPZ-induced demyelination in the corpus callosum

The mechanism does not involve receptor downregulation or tolerance in any known way, but the signal-to-noise ratio is simply too low based on available evidence

In an open-label phase 1 clinical trial, 17 male patients with ED after radical prostatectomy were insensitive to PDE5I and ICI