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doi: 10.48307/FMSJ.2024.28.5.500 61

However, standard reduced Glutathione (GSH) is often unstable and therefore has low bioavailability when taken orally

[14] The authors observed that the cortical response to transcranial magnetic stimulation (TMS) was significantly enhanced after neurofeedback, persisted for at least twenty minutes, and was correlated with an EEG time-course indicative of activity-dependent plasticity [14] A review of the relevant scientific literature has shown that systematic cognitive load from working on a computer (specifically, training subjects to monitor their brain functions by measuring brain waves and providing feedback), with a total training duration of 16 hours (a few hours of weekly performance), can affect brain structure and function depending on how the impact is performed

According to the European Medicines Agency assessment report on HPL, lyophilized 65% ethanol extracts (5:1, 100 mg of extracts were equivalent to 500 mg of HPL) were standardized to 0.3% hypericin and contained 1.09% rutin, 0.65% hyperoside, 0.45% isoquercitin, 0.04% quercitrin, and 0.07% quercetin (the HPL flavonoid content determination is described in Supplementary method I, Supplementary Figure S1, and Supplementary Tables S1, S2)