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We reasoned that mouse models of 22q11.2DS might have metabolic disturbances similar to those reported in patients, in which case the in vivo genetic and pharmacological manipulation of the model should provide insights into the contribution of the metabolic phenotypes to the disease pathogenesis and/or disease mechanisms

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In the Phase I/II trial, 27% of patients with indolent lymphoma achieved objective clinical responses at distant, noninjected tumor sites following intratumoral injection of the TLR9 agonist PF-3512676 combined with low-dose radiotherapy, including one complete and three partial responses

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