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Nishida K, Takeuchi K, Hosoda A, Sugano S, Morisaki E, Ohishi A, et al

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Because E, L, P selectins recognise and bind to epitopes containing the carbohydrate sLe x of glycoprotein or glycolipidon on a cell surface

In a 3-month open trial of vitamin B12 nasal drops involving 51 ME/CFS patients, 34 responders showed improved physical activity and fatigue scores, with these clinical benefits correlating with a marked increase in serum B12 levels from 328 pmol/L to 973 pmol/L [127]