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PIK3CA mutation status was prospectively determined in a central laboratory using the FoundationOne Liquid CDx assay on plasma-derived circulating tumor DNA (ctDNA) or in local laboratories using various validated polymerase chain reaction (PCR) or next-generation sequencing (NGS) assays on tumor tissue or plasma

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Meal replacement shakes may also be fortified with B vitamins

For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine