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Scientific understanding on how the formulation, the inhalation device and relevant physiology impacts the drug product performance is the mainstay of an inhaled biopharmaceutics representative assignment in the industrial setting

doi: 10.1371/journal.pone.0005650 32 SnellingSJForsterAMukherjeeSPriceAJPoulsenRC

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Astrocytes, positioned at the interface between the brain parenchyma and the perivascular space, which includes capillaries, larger arteries, and veins [66], play a role in the removal of A from the brain via mechanisms that include enzymatic degradation of A and the upregulation of efflux transporters for A at the BBB [67]