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Clinically, two independent cohorts confirm relevance: German CAR-T patients with high fecal pentanoate (74.1 g/g) had a 1-year PFS of 90% vs

However, annexin V labels apoptotic cells independently of the apoptotic pathways they underwent and as extrinsic apoptosis does not involve mitochondrial disruption it can be a plausible explanation for these results

Mtb-secreted antigens (PPE36, EspC, or Rv1987), heat-shock proteins (Hsp16.3), or genes like Rv2882c have been demonstrated to polarize macrophages in vitro or in mouse models, via the activation of crucial intracellular processes and the generation of soluble factors (Guo et al., 2019

Patients are monitored for symptom change, weight change, quality of life, and diabetes management with blood samples drawn to test for HbA1c levels every 6 months for 24 months