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Inflammatory signaling disrupts insulin action in adipocytes and hepatocytes by impairing key components such as IRS-1, the insulin receptor, and peroxisome proliferator activated receptor gamma (PPAR), thereby exacerbating metabolic dysfunction (53)

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Limitations of Preclinical Studies and Translation Barriers The translational potential of current preclinical evidence for human pulmonary hypertension (HPH) faces significant limitations and hurdles