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Tsai PH, Liu JJ, Chiu WC, Pai MH, Yeh SL

Acta Pharmacol Sin 41:471482

These conflicting findings could be attributed to variations in the source of GPX3, whether derived primarily from the kidneys or locally expressed and secreted by bronchial epithelial cells

Despite spermidine-generated ROS being a possible upstream signal in activating the latter ATM pathway 206 , spermidine appears to act as direct ROS scavengers, resulting in inhibition of mitochondrial ROS production 211,212