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elegans FP::IFDs, also appearing in the axon, nucleus, and in filamentous patterns in the cytoplasm in some neurons (Supplementary Fig

[59] Gla proteins are known to occur in a wide variety of vertebrates: mammals, birds, reptiles, and fish

However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)