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Subsequently, 5,10-meTHF is transformed into the highly oxidized folate species, 10-formyl-THF

Notably, these mechanisms not only collectively safeguard cutaneous structural and immunological integrity, but also orchestrate a dynamic regulatory network in response to exogenous stimuli (e.g., UV radiation, oxidative stress) and endogenous inflammation

Unlike oral supplements that may have limited absorption, IM injections ensure 100% bioavailability of this vital nutrient that's crucial for red blood cell formation, nerve function, DNA synthesis, and overall metabolic health

Funding This work was supported by Yokohama City University Personal Research Grant