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Chronic inflammation leads to dysfunction of the endometrium by influencing the proliferation and apoptosis of endometrial cells, thereby increasing the risks of endometrial hyperplasia, PCOS, and cancer ( 3.7 Gut microbiota The gut microbiota, often referred to as the human bodys second genome ( Additionally, PCOS is associated with an increased abundance of Gram-negative bacteria ( e.g ., Enterobacteriaceae), which produce lipopolysaccharide (LPS)

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Bactericidal medications frequently kill Escherichia coli cells by causing the Fenton reaction, which produces very reactive hydroxyl radicals