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Diet and amino acid uptake Under normal physiological conditions, the rate of GSH synthesis is largely determined by two factors, cysteine availability and GCL activity

Importantly, GDH1 knockdown elicited more pronounced inhibition on in vivo tumor growth, as shGDH1 Huh7 cells failed to grow into detectable xenografts and shGDH1 H1299 xenografts grew much more slowly than the control cohort (Extended Data Fig

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