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doi: 10.1016/j.jid.2017.08.038 106 NizardMRousselHDinizMOKarakiSTranTVoronTet al

LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport

Galectins are galactose-binding proteins often expressed on the extracellular surface of cell membranes, making them potentially useful surface markers for following senescence in living cells