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In the traumatic brain injury model, SDC-1 in rat cerebral tissue decreased while increased in serum

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA

EDCs induce oxidative stress, which generates errors in methylation that affect the methylome

Using an in vitro PHGDH enzyme assay, they determined CBR-5884 to be a weak and selective PHGDH inhibitor (IC 50 = 33 12 mM), whose mode of action involves the disruption of the enzymes tetrameric state in favour of the dimeric conformation 20