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LCMS/MS glycomics of idiopathic rapid eye movement sleep behavior disorder

Venglustat , a brain penetrant small molecule inhibitor of glycosylceramide synthase has failed to show an effect on progression of MDS-UPDRS part II+III scores after 52 weeks of treatment in a double-blind, placebo-controlled trial despite evidence for target engagement, i.e

Oral supplementation is preferred over injections during pregnancy

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