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L., Li, T., Li, J

The pROC R package was used to calculate the area under the ROC curve (AUC), enabling the identification of the top features (pathways and genes) with high AUC values

Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease