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One study looked at 84 patients with marginal ulcers and described the appearance as single or multiple infiltrates, which subsequently coalesced with overlying epithelial breakdown of the corneal epithelium

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doi: 10.1517/17425255.2.3.351 99 YamasakiMMakinoTMasuzawaTKurokawaYMiyataHTakiguchiSet al

In this mouse model, 7585% decrease of Gpx4 was shown to induce hippocampal neuronal loss, lipid peroxidation, neuroinflammation and spatial learning deficits (Hambright et al., 2017)