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In one study, FI-SARS-CoV reduced viraemia and protected against lung pathology in rhesus macaques 124 , whereas in another study macaques given FI-SARS-CoV developed macrophage and lymphocytic infiltrates and alveolar oedema with fibrin deposition after challenge, indicating the difficulties of establishing consistent NHP models 125

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To assess this issue, we conducted exome sequencing experiments with intestinal tumors from both genotypes and noticed that the mutational rate was more elevated in tumors from Apc +/Min /Stard7 IEC mice (Fig

PPI-based regimens have long been used with not-so-satisfactory eradication and problems with drug resistance