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Mitochondria produce ROS during adenosine triphosphate (ATP) generation, with some electrons leaking from the electron transport chain (ETC), which subsequently leads to superoxide anion production [66]

In addition, a low level of GPx3 is an independent predictive marker of the local recurrence of early-stage invasive breast cancer in patients undergoing breast-conserving surgery and radiotherapy, regardless of the patients clinicopathological parameters [104]

Though, some anecdotal reports have suggested adverse side effects including nausea, vomiting, diarrhea, and allergic reactions (e.g., skin rash)

Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases